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Adipocytokines and fetal fat accretion in pregnant teens
Author(s) -
Whisner Corrie Marie,
Pressman Eva K,
Young Bridget E,
Cooper Beth E,
Queenan Ruth A,
O'Brien Kimberly O
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.111.8
Subject(s) - adiponectin , medicine , fetus , cord blood , leptin , gestation , adipokine , gestational age , pregnancy , birth weight , endocrinology , obstetrics , cord , weight gain , physiology , obesity , biology , body weight , surgery , insulin resistance , genetics
Shifts in energy metabolism required for fetal development are mediated by adipokines; this process may be uniquely altered in pregnant teens undergoing continued growth across pregnancy. To assess hormonal factors of fetal fat accretion, maternal and cord blood were obtained in 171 pregnant teens (age 13–18 y). Fetal biometry and fetal abdominal wall thickness (FetalAbFat), a measure of fetal subcutaneous fat, were obtained from sonograms. Leptin and adiponectin were analyzed in maternal serum at mid‐gestation and delivery and in cord blood. Of the teens studied, 68% were Black and 32% were Caucasian; mean gestational weight gain (GWG) was 17.3 ± 8.1 kg. FetalAbFat at late gestation (34.7 ± 2.7 wks; range 26.9 – 41.0 wks) averaged 0.47 ± 0.14 cm; mean birth weight (BW) at delivery was 3322.5 ± 480.9 g. Maternal leptin and adiponectin did not differ by race but cord adiponectin was significantly ( P <0.001) greater in Caucasian neonates. FetalAbFat was not linked with maternal or cord adiponectin (n=50 maternal‐neonatal pairs) but a positive trend ( P =0.07, n=112 maternal‐neonatal pairs) was observed for cord leptin. Infant BW was positively related with cord leptin ( P <0.0001), cord adiponectin ( P <0.03) and FetalAbFat ( P <0.001). In spite of GWG similar to adult women, teens often suffer lower BWs suggestive of a need for more data on determinants of fetal growth and fat accumulation in pregnant adolescents. Grant Funding Source : USDA/NIFA Grant No. 2012–67012‐19815, 2005–35200