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Maternal‐fetal vitamin D status and child bone health
Author(s) -
Huh Susanna Y,
Aspinwall Sarah B,
RifasShiman Sheryl L,
Camargo Carlos A,
Gordon Catherine M,
Litonjua Augusto A,
Gillman Matthew W
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.111.3
Subject(s) - medicine , cord blood , vitamin d and neurology , bone mineral , fetus , umbilical cord , cord , dual energy x ray absorptiometry , cohort , prospective cohort study , vitamin d deficiency , bone health , obstetrics , pregnancy , osteoporosis , surgery , biology , anatomy , genetics
Objective To examine whether maternal‐fetal vitamin D status is associated with child bone health. Methods In a prospective U.S. pre‐birth cohort, we studied 724 mother‐child pairs with 2 nd trimester or cord 25(OH)D levels and dual‐energy X‐ray absorptiometry skeletal measures at 6.6–10.6 years. Results Mean (SD) 2 nd trimester and cord blood 25(OH)D levels were 59 (22) and 45 (18) nmol/L, respectively. 25(OH)D levels were <50 nmol/L in 33% of 2 nd trimester and 61% of cord blood samples. After covariate adjustment, neither 2 nd trimester nor cord blood 25(OH)D were associated with total body bone mineral content (BMC) or areal bone mineral density (aBMD) (Table). Conclusions 2 nd trimester and cord blood 25(OH)D levels were not associated with child bone health. Funded by NIH R01 grants HL064925, HD034568