Premium
Voluntary activity is blunted following undernutrition in early life
Author(s) -
Fiorotto Marta L.,
Scull Brooks,
Davis Teresa A,
Fleischmann Ryan
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.111.1
Subject(s) - offspring , ambulatory , turnover , zoology , medicine , sed , endocrinology , malnutrition , casein , energy expenditure , lactation , litter , biology , pregnancy , food science , genetics , management , economics , agronomy
We investigated if undernutrition (UN) in the neonatal period of the mouse has any long‐term impact on activity following nutritional rehabilitation. Newborn pups born to control dams were cross‐fostered to dams fed either a low protein (8 % casein) or a control (CON; 20% casein) diet. On postnatal (PN) d 22 female offspring (n=18–20/diet) were weaned to the CON diet and individually housed in metabolic cages for measurement of energy expenditure, food intake, and ambulatory cage activity until PN43; half the mice also had access to free running wheels (FW). Body wt and composition (by QMR) were measured at PN22 and PN43. At PN22 and PN43, body wt of UN pups were 75% and 88% those of CON (P<0.001) and not alterd by FW. Lean gain as % body wt gain was greater in FW than sedentary (SED) pups and similar in UN and CON mice. Daily running distance increased with age, but UN pups ran only 46% the distance of CON pups (P<0.001); the difference was greater at PN43 than PN22 (P<0.02). Ambulatory activity was unaffec ted by preweaning UN and was greater in FW than SED pups (P<0.01). Differences in food intake and energetic efficiency could not account for the difference in FW running between groups. UN in early life reduces voluntary running, but not ambulatory, activity, and this response is not reversible upon nutritional rehabilitation. (Supported by NIH AR46308 and USDA/ARS 6250–51000‐054)