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Obesity and insulin resistance in adolescents: impact of renin angiotensin system
Author(s) -
Fernandes Fernanda Barrinha,
Fernandes Adriana Barrinha,
Silva Febba Andreia Cristina,
Souza Vitale Maria Sylvia,
Jung Flavia Fernandes,
Casarini Dulce Elena
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1109.5
Subject(s) - medicine , endocrinology , insulin resistance , bradykinin , renin–angiotensin system , angiotensin ii , insulin , angiotensin iii , chemistry , obesity , blood pressure , angiotensin ii receptor type 1 , receptor
The aim of this study was to evaluate the relationship between obesity and plasma Angiotensin levels [Ang I, Ang II, Ang (1–7)], Bradykinin (BK) and the presence of insulin resistance (IR). Subjects (n=104) were divided according with HOMA IR and classified as presence of RI (RI+) and absence of insulin resistance (IR−). The Ang I, Ang II, Ang (1–7), BK and Vasopressin (VP) plasmatic levels had been measured by HPLC. The RI+ group had more values of skinfolds, WHR, BMI, leucocytes, uric acid, glucose, insulin, VP, triglycerides, C reactive protein, Des Arg9‐BK, Ang I and lower plasmatic levels of Ang (1–7) and BK. Our results showed a reduction of Ang (1–7) and increased of Ang I associated with weight gain and IR in adolescents suggesting a modulation of Angiotensin Converting Enzyme 2 and Neutral Endopeptidase. Ang (1–7) and BK low levels may contribute to the development of hypertension and inflammatory conditions in obese adolescents with alterations of glucose and insulin metabolism, since these can resulting in cardiovascular target organ damage such as the heart, the vascular wall and the kidney. (Supported by Fapesp and CNPq)