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Effects of aerobic exercise training on obese female mice: metabolic and autonomic evaluation
Author(s) -
Sartori Michelle,
Souza Leandro Eziquiel,
Souza Pamella Ramona,
Santos Fernando,
De Angelis Kátia,
Irigoyen Maria Claudia
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1109.1
Subject(s) - blood pressure , medicine , heart rate , aerobic exercise , baroreflex , interval training , endocrinology , treadmill
The aim of this study was to evaluate the metabolic and autonomic parameters in trained youth obese mice. Female ob/ob mice (4 weeks old) were randomized into sedentary (OS, n=11) or trained (OT, n=8) (treadmill,5 days/w, 60 min/d, during 8 wks) groups. Blood glucose was measured by reagent strips. Blood pressure signals were recorded using a data acquisition system. The OT group had higher exercise capacity compared to the OS group. OT group had reduced body weight, white adipose tissue and blood glucose (45±2g, 6.1±1g and 133±3g mg/dL) compared to OS group (50±2g, 6.1±1g and 169±8 mg/dL). Exercise training improved glucose tolerance in trained group (OS: 27961±6501 vs. OT: 18258±6283 mg/dL/min). Mean arterial pressure and heart rate were similar between groups. The trained group showed increase in heart rate variability compared with sedentary group (OT: 50±12 vs. OS: 33±8ms 2 ). Blood pressure variability and low frequency band were higher in OS group (23 ± 3mmHg 2 and 7 ± 1 mmHg 2 ) compared to OT (15 ± 2 mmHg 2 and 5 ± 1 mmHg 2 ). Moreover, the spontaneous baroreflex sensitivity, represented by alpha index, was lower in sedentary group (1.2 ± 0.3 ms/mmHg) compared to trained group (1.9 ± 0.2 ms/mmHg). In conclusion, our results suggest that physical training during lifespan can be effective inattenuating the increase in weight and blood glucose and improving blood pressure variability in obese mice. FAPESP 2011/20859–0