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Allicin inhibits metastasis of MCF‐7 cells by inhibition of VCAM‐1 expression
Author(s) -
LEE Chung Gi,
Pyo Suhkneung
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1105.12
Subject(s) - allicin , allium sativum , chemistry , metastasis , western blot , cancer research , cancer cell , downregulation and upregulation , cell migration , cell adhesion , cell adhesion molecule , vcam 1 , mcf 7 , cell , biology , microbiology and biotechnology , cancer , biochemistry , human breast , botany , genetics , gene
Adhesion molecules play a key role in tumour development and are involved in processes that allow cancer cell migration, tissue invasion and metastasis formation. Allicin, the major component of Garlic (Allium sativum) was examined for the ability to inhibit metastasis and the mechanism of the inhibition of metastasis in human breast cancer cells. Western blot analysis showed that cells pretreated with various concentrations of allicin (0.1–10 ng/ml) resulted in decrease in the levels of VCAM‐1 and p65 expression, whereas ER‐α expression was increased by allicin in TNF‐α‐treated cells. Allicin treatment also inhibited p65‐ER‐α complex formation induced by TNF‐α. In addition, cell migration and invasion assays showed that allicin inhibited the migration and invasion of MCF‐7 cells. Taken together, the present data suggest that allicin inhibits the migration and invasion of MCF‐7 cells, and the effect is likely associated with inhibition of p65‐ER‐α complex formation and downregulation of VCAM‐1 expression.