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Cannabidiol attenuates the long lasting cognitive deficits and anxiogenic‐like behaviors promoted by murine cerebral malaria
Author(s) -
Campos Alline Cristina,
Miranda Aline S,
Brant Fatima,
Rocha Natalia P,
Machado Fabiana S,
Rachid Milene A,
Guimarães Francisco S,
Teixeira Antonio L
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1097.9
Subject(s) - cannabidiol , anxiogenic , elevated plus maze , medicine , plasmodium berghei , artesunate , neuroprotection , nootropic , anxiolytic , pharmacology , parasitemia , anxiety , plasmodium falciparum , malaria , anesthesia , cannabis , psychiatry , immunology
Cerebral malaria (CM) is a severe complication resulting from Plasmodium falciparum infection that causes permanent neurological and behavioral deficits after infection resolution by antimalarial drugs. Cannabidiol (CBD) is the major nonpsychotomimetic constituent of Cannabis sativa with neuroprotective properties. The present work aimed to determinate if CBD treatment could prevent behavioral changes found in mice infected by Plasmodium berghei‐ANKA (PbA). Female C57Bl6 mice were infected or not with PbA (10茐 parasitized/0.2 mL PBS i.p.). On day 3 after infection (dpi) all groups receive the first injection of CBD (30mg/Kg/day‐7 days) or vehicle. On 5dpi, infected animals started to be treated with artesunate (32mg/kg/day‐5 days i.p). Five days after completed clearance of parasitemia, all groups were submitted to the Object Recognition task (OR) and to the Elevated Plus Maze (EPM). After completed clearance of the paraesitemia by artesunate, PbA vehicle treated mice displayed memory deficits in the OR (represented by decrease in the % of new object index) and exhibited an increase in anxiety‐like behaviors in the EPM. Cannabidiol treatment was able to prevent long lasting anxiogenic and cognitive impairment found in PbA mice. Our results indicate that CBD could be useful as an adjunctive therapy to prevent brain damage during the course of CM.