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Leptin and resistin are influenced by increased body fat measurements in pregnant women
Author(s) -
Ozias Marlies K,
Li Shengqi,
Lin PingChang,
Schmitt Allan,
Hull Holly R,
Carlson Susan E
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.109.2
Subject(s) - resistin , adipokine , leptin , medicine , adiponectin , endocrinology , adipose tissue , pregnancy , obesity , biology , insulin resistance , genetics
Our objective was to determine if adipokine concentrations were associated with total body fat, subcutaneous (SF) and visceral abdominal fat (VF) in obese (O) and normal weight (N) pregnant women. Plasma adipokines (leptin, adiponectin, visfatin, and resistin) were measured in 5 O and 9 N pregnant women (no pre‐eclampsia or GDM) after 35 wks gestation by EIA (Alpco Diagnostics; Phoenix Pharmaceuticals). We grouped women based on subject‐reported pre‐pregnancy weight and height. Total body fat was measured 2‐wks postpartum by iDXA (GE Healthcare). SF and VF were measured with Image J software from MRI (Siemens Skyra 3T) abdominal axial scans (5.0mm; 5.0mm gap) of vertebral L2‐S3. Statistical analyses involved t‐tests between groups and simple linear regression to compare adiposity measurements to adipokine concentrations. Leptin increased in O vs N (74 vs. 31 ng/mL, P < 0.001) and was associated with total body fat mass (r = 0.843; P < 0.001), SF (r = 0.649; P = 0.012) and VF (r = 0.618; P = 0.019). Resistin was only associated with SF (r = 0.538; P = 0.038). O women had significantly more SF (2137 vs. 706 g; P = 0.041) but not VF (290 vs. 103 g; P = 0.117) compared to N women. In pregnancy, elevated leptin concentration was associated with all measures of adiposity while resistin was only associated with SF. These findings suggest that increased leptin may be an accurate biomarker of adiposity during pregnancy. Grant Funding Source : Sam E. and Mary F. Roberts Endowment, NICHD HD02528, NIH S10 RR029577 and UL1 TR1