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Vitamin D Status Impacts Serum Metabolomic Profiles in Pregnant Adolescents
Author(s) -
Finkelstein Julia L.,
Pressman Eva K.,
Cooper Elizabeth M.,
Kent Tera R.,
O'Brien Kimberly O.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1080.2
Subject(s) - metabolomics , chemistry , xanthine oxidase , vitamin d and neurology , medicine , oxidative stress , metabolite , endocrinology , biochemistry , chromatography , enzyme
This study was conducted to identify the impact of vitamin D status on metabolomic profiles in pregnancy. Metabolomic studies were performed in a group of 30 pregnant, African‐American adolescents at mid‐gestation (27 weeks), with serum concentrations of 25(OH)D >;20 ng/mL (n=15, 28.3 ± 4.7 ng/mL) and 25(OH)D <20 ng/mL (n=15, 10.4 ± 2.0 ng/mL). Global biochemical profiles were determined in serum samples using gas chromatography‐mass spectrometry and liquid chromatography‐tandem mass spectrometry. Two‐sample t‐tests were used to identify biochemicals that differed significantly between groups. In metabolomic analyses, heme and the antioxidants bilirubin and gamma‐CEHC were significantly higher in serum from teens with 25(OH)D >;20 ng/mL. Greater vitamin D status was associated with significantly elevated oxidase enzymes, xanthine, pyridoxate, and N1‐Methyl‐2‐pyridone‐5‐carboxamide. Concentrations of ribitol, xylose and catechol sulfate were also significantly higher in the vitamin D sufficient group. Lower vitamin D status was associated with increased biochemical parameters related to inflammation, oxidative stress, and altered gut microbiome metabolism. Funded by USDA 2005–35200‐15218 and USDA 2010–34324‐20769.