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Ex vivo anti‐adhesion activity of a proanthocyanidin standardized cranberry powder beverage
Author(s) -
Kaspar Kerrie L,
Howell Amy B,
Khoo Christina
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1079.42
Subject(s) - cranberry juice , proanthocyanidin , ex vivo , urine , placebo , in vivo , food science , urinary system , adhesion , chemistry , hemagglutination , medicine , pharmacology , microbiology and biotechnology , in vitro , antioxidant , immunology , biochemistry , biology , pathology , polyphenol , antigen , alternative medicine , organic chemistry
Cranberry bioactives have been studied for their bacterial antiadhesion effect, which may prevent uropathogenic Escherichia coli ( E. coli ) from entering epithelial cells in the bladder. In this study, we compared the ex vivo urinary anti‐adhesion activity of a lowcalorie cranberry powder beverage (CPB) to a low‐calorie cranberry juice cocktail (LCJC) in healthy adults. The CPB was standardized to be equivalent to LCJC on a proanthocyanidin basis. Fifty‐nine volunteers participated in a double‐blind, randomized, placebo‐controlled, cross‐over study. Clean‐catch urine samples collected at baseline and 0–6 h were tested for anti‐adhesion activity utilizing a mannose‐resistant human red blood cell hemagglutination assay specific for P‐fimbriated E. coli . Compared to placebo, 0–6 h post‐consumption urines from the CPB and LCJC groups had significantly higher ( p <0.05) antiadhesion activity compared to baseline. Although the CPB beverage demonstrated a greater anti‐adhesion activity post‐consumption compared to LCJC, there were no significant differences between these treatments ( p =0.14), indicating a similar effect. Acute cranberry beverage consumption increased urinary anti‐adhesion activity ex vivo. This research was supported by Ocean Spray Cranberries, Inc.