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Padiococcus Acidilactici (PA) Isolated from traditional Makgeolli inhibits lipid accumulation in 3T3‐L1 adipocyte and obesity in C57BL/6J mice fed a high‐fat diet
Author(s) -
Moon YeonJeong,
Baik SangHo,
Cha YounSoo
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1079.39
Subject(s) - triglyceride , lipid metabolism , adipocyte , adipose tissue , chemistry , obesity , fatty acid , fatty acid synthase , in vivo , endocrinology , fatty acid synthesis , oil red o , medicine , food science , biochemistry , biology , cholesterol , microbiology and biotechnology , adipogenesis
Korean traditional alcoholic beverage ‘Makgeolli ’, is a type of rice beer typically prepared using steamed rice and nuruk. This study investigated the anti‐obesity effect of PA ( Padiococcus Acidilactici ) extract on in‐vitro and in‐vivo . PA extract treatment decreased the triglyceride (TG) level and the Oil red O staining in cultured 3T3‐ L1 adipocytes. For in‐vivo study C57BL/6J male mice, were randomly divided into ND (ND normal group), HD (HD high fat diet group), HDA (HD plus reference strain) and HDB (HD plus PA) groups. The lyophilized strains were orally administrated with a final concentration of 1.25 × 10 9 cfu/g for 12 weeks. HDB group showed lower final bodyweight, adipose tissue weight and serum lipid profile. Also, the activity of fatty acid synthase (FAS), a key enzyme of fatty acid synthesis, was markedly suppressed in the HDB, as compared to the HD group. We suggest PA extract may exert an anti‐obesity effect in C57BL/6J mice by enhancing the lipid metabolism (This research was supported by the Globalization of Korean Foods R&D program, funded by the Ministry of Food, Agriculture, Forestry and Fisheries, Republic of Korea).