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Pooled Analysis of Impact of Lycium barbarum Fruit (Goji) Intake on Central Adiposity, Sleep Quality and General Well‐being: Randomized, Double‐blind, Placebo‐controlled Human Clinical Studies
Author(s) -
Amagase Harunobu,
Hsu ChiuHsieh,
Nance Dwight M
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1079.1
Subject(s) - lycium , waist , pittsburgh sleep quality index , medicine , placebo , postprandial , obesity , randomized controlled trial , zoology , endocrinology , sleep quality , insomnia , diabetes mellitus , biology , pharmacology , alternative medicine , pathology
Obesity has negative impacts on sleep and other conditions. Lycium barbarum intake has been shown to improve general well‐being, sleep quality (SQ) and postprandial energy expenditure, and to reduce central adiposity in multiple randomized, double‐blind, placebo‐controlled trials. To assess possible interactions among these parameters, we analyzed pooled data from these trials (n=102, mean age=33 y) using 2‐sample t‐test and scatter plot with linear regression. SQ and general well‐being were evaluated by Pittsburgh Sleep Quality Index (PSQI) and subjective questionnaire, respectively, and waist circumference (WC) was assessed pre‐ and post‐dietary intervention with Lycium barbarum for 2–4 weeks. Results indicated that PSQI scores were correlated with SQ, increased general complaints about well‐being and increased WC. Lycium barbarum intake significantly improved SQ (p=0.021) and general well‐being (p=0.001), and reduced WC (p=0.002) compared to placebo. Correlations among these parameters were: sleep vs general well‐being, 0.31 (p=0.002); sleep vs WC, −0.04 (p=0.747); and general well‐being vs WC, − 0.25 (p=0.039). These correlations suggest that diet‐induced improvement in general well‐being is associated with improved SQ and is negatively correlated with changes in WC. These suggest that Lycium barbarum intake may stimulate metabolism and could contribute to an obesity management program.