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Influence of lactation and choline intake on one‐carbon biomarkers in women
Author(s) -
Davenport Crystal,
Shields Kelsey,
Yan Jian,
Jiang Xinyin,
Malysheva Olga,
Caudill Marie,
Stabler Sally,
Allen Robert
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1077.9
Subject(s) - lactation , choline , medicine , homocysteine , endocrinology , betaine , methionine , chemistry , metabolism , urine , pregnancy , amino acid , biology , biochemistry , genetics
Objective We sought to quantify the effects of lactation and maternal choline intake on maternal indicators of one‐carbon metabolism. Methods Lactating (n = 28; 30‐d post‐partum) and nonlactating (NL, n = 21) women were randomized to choline intakes of 480 or 930 mg/d for 10 weeks. Blood and urine were collected at baseline, study midpoint, and study end for analysis of one carbon metabolites. Results Compared to NL women, lactating women exhibited elevated plasma choline (p=0.04) and decreased urinary dimethylglycine losses (p=0.008). Within lactating women, a higher choline intake yielded greater plasma betaine (p=0.015), greater plasma dimethylglycine (p=0.037), greater plasma methylglycine (p=0.036), and decreased plasma cystathionine (p=0.012). However, higher choline intake did not affect plasma concentrations of homocysteine, cysteine, methionine, or glycine. Conclusions Lactation and choline intake influence biomarkers of 1‐C metabolism with some evidence of a greater demand for choline during lactation and a positive effect of a higher choline intake on methyl group supply.