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Response of vitamin B12 status to a controlled B12 intake in nonpregnant, pregnant, and lactating women
Author(s) -
Bae Sajin,
West Allyson A,
Yan Jian,
Jiang Xinyin,
Perry Cydne A,
Caudill Marie A
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1077.10
Subject(s) - medicine , pregnancy , gestation , vitamin b12 , endocrinology , vitamin , lactation , biology , genetics
As part of a 12‐wk controlled feeding study, pregnant (n=26, 27 wk gestation), lactating (n=28, 5 wk postpartum), and nonpregnant (n=21) women consumed the study vitamin B 12 dose of 7.5 μg/d [prenatal supplement (2.6 μg/d) and natural food (~4.9 μg/d)]. All participants achieved adequate vitamin B 12 status throughout the study. Serum total vitamin B 12 remained constant in pregnant and lactating women, whereas it increased in nonpregnant women (P=0.001). At study end, total B 12 (mean ± SD) was lower in pregnant women (335 ± 104 pmol/L) than lactating (496 ± 127 pmol/L, P<0.001) and nonpregnant (422 ± 82 pmol/L, P=0.015) women. The consumption of the study B 12 dose increased both serum holotranscobalamin (holoTC) and the fraction of total serum vitamin B 12 bound to TC (holoTC/B 12 ratio) within physiologic groups (P ≤0.001 and P ≤0.037, respectively). At study end, pregnant women had higher holoTC/B 12 ratio (31%) than nonpregnant women (22%, P=0.035) and lactating women (24%, P=0.056) suggesting that pregnancy increased the tissue availability of circulating B 12 . Overall, these data suggest that consumption of the study vitamin B 12 dose (~ 2.5 times the RDA) met the vitamin B 12 requirements of our study participants and maintained B 12 concentrations in third trimester pregnant women by increasing holoTC concentrations. Funded in part by USDA, AEB‐ENC and the Beef Checkoff.