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Plasma n‐3/n‐6 PUFAs interact with FADS2 genetic variations to affect blood cholesterol concentrations in type 2 diabetes
Author(s) -
Huang MengChuan,
Huang PeiChi,
Chung HsinFang,
Hsu ChihCheng
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1072.8
Subject(s) - fads2 , polyunsaturated fatty acid , medicine , single nucleotide polymorphism , percentile , linoleic acid , cholesterol , endocrinology , confounding , type 2 diabetes , diabetes mellitus , chemistry , fatty acid , docosahexaenoic acid , biochemistry , genotype , gene , statistics , mathematics
Single nucleotide polymorphisms (SNPs) of fatty acid desaturase (FADS) and n‐3/n‐6 polyunsaturated fatty acids (PUFAs) have been linked to decreased risks of cardiovascular diseases. We aimed to examine whether FADS SNPs (rs2072114, rs1535, and rs174546 ) interacted with n‐3/n‐6 PUFAs status as plasma levels to affect blood lipid profiles in type 2 diabetes. In 2008, we selected 192 diabetic patients without using lipid‐lowering drugs from a diabetic (DMIDS) cohort established in Taiwan. After adjusting for confounding factors, FADS2 rs2072114 G‐variant correlated significantly with decreased total cholesterol (p‐trend=0.015), LDL (p‐trend=0.009), and HDL (p‐trend=0.007) only in the low (<50 percentile) alpha‐linolenic acid (ALA)/linoleic acids (LA) group but not in the high (≥50 percentile) ALA/LA group (p for interaction= 0.012, 0.012, and 0.181, respectively). Furthermore, the G‐variant was significantly associated with lower total cholesterol (p‐trend=0.049) and HDL (p‐trend=0.024), and marginally with LDL (p‐trend=0.067) in the low n‐3 long chain PUFA (LCPUFAs) group (<50 percentile) but not in the high n‐3 LCPUFAs (≥50 percentile) (p for interaction= 0.170, 0.053, and 0.015, respectively). Genetic variations of FADS2 may interact with n‐3/n‐6 PUFAs to affect cholesterol metabolisms in type 2 diabetes. Further investigation may be needed with larger sample size in this ethnic population.