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Protective effects of different dietary proportion of fish oil on hepatic injury in chronic ethanol‐fed rats
Author(s) -
Yang SuhChing,
Peng HsiangChi,
Chen YaLing,
Liao WeiHsiang,
Wang XiangDong
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1072.3
Subject(s) - fish oil , ethanol , triglyceride , alcohol , chemistry , oxidative stress , alanine aminotransferase , medicine , cholesterol , fatty liver , glutathione , zoology , endocrinology , food science , fish <actinopterygii> , biochemistry , biology , fishery , enzyme , disease
Excess consumption of alcohol is known to cause liver damage. The present study was to investigate the effects of different proportions of fish oil on hepatic aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and oxidative stress in ethanol‐fed rats. Male Wistar rats were divided into six groups (n=5/group) and fed with either the control diet or the alcohol diet, in which the fat composition of both diets was adjusted with 25% or 45% fish oil substitution for olive oil. The groups were C (control), 25%CF (control with 25% fish oil), 45%CF (control with 45% fish oil), E (ethanol), 25%EF (ethanol with 25% fish oil), and 45%EF (ethanol with 45% fish oil). Rats were sacrificed after 8 weeks of the treatments. Results showed that plasma levels of AST, ALT activities, 8‐isoprostaglandinF 2α , triglyceride and total cholesterol were significantly decreased and hepatic GSH/GSSG ratio was significantly increased in the 25%EF and 45%EF groups than those in the E group (p<0.05). In addition, the pathologic scores for microvesicular fatty change, degeneration and necrosis were significantly decreased in 25% EF and 45% EF groups as compared with that in the E group (p<0.05). The results suggested that fish oil substitution could prevent ethanol‐induced liver damage . Supported by NSC100–2320‐B‐038–023‐MY3.