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Erythrocyte levels of omega‐3 polyunsaturated fatty acids were negatively associated with the risk of rheumatoid arthritis in Korean women
Author(s) -
Lee Aeri,
Park Yongsoon
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1072.12
Subject(s) - polyunsaturated fatty acid , arachidonic acid , eicosapentaenoic acid , rheumatoid arthritis , medicine , fatty acid , endocrinology , immunology , gastroenterology , chemistry , biochemistry , enzyme
The purpose of the present study was to investigate the hypothesis that erythrocyte level of the omega‐3 PUFAs is associated with the risk of RA and indicators of RA activities in women with RA. One hundred and one female RA patients and one hundred thirty two healthy women were participated, and erythrocyte fatty acid composition and RA disease activities were evaluated. Erythrocyte levels of α‐linolenic acid (18:3n3; ALA), eicosapentaenoic acid (EPA; 20:5n3), and Omega‐3 Index were significantly lower in RA patients than healthy controls. Multivariable‐adjusted regression analysis showed that a higher level of ALA, EPA, and the ratio of EPA/arachidonic acid significantly decreased the risk of RA after adjusting for body weight and smoking status. PGE 2 concentration was also inversely related with the level of erythrocyte DHA among RA patients. In addition, the risk of RA and RA disease activities were positively associated with erythrocyte levels of arachidonic acid, saturated fatty acids, and trans fatty acid. In conclusion, erythrocyte levels of omega‐3 PUFAs were associated with decreased risk for RA in Korean women. (This work was supported by the Korea Research Foundation Grant 2010–0008656.)