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Sedentary behavior and mortality in older women
Author(s) -
Seguin Rebecca,
Buchner David,
Liu Jingmin,
Allison Matthew,
Manini Todd,
Manson JoAnn,
Messina Catherine,
Patel Mahesh,
Moreland Larry,
LaCroix Andrea
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1068.7
Subject(s) - medicine , demography , confounding , hazard ratio , body mass index , proportional hazards model , quartile , context (archaeology) , prospective cohort study , cohort study , gerontology , national death index , sedentary lifestyle , observational study , ethnically diverse , physical activity , confidence interval , population , physical therapy , environmental health , sociology , paleontology , biology
CONTEXT Sedentary behavior has been associated with poor health outcomes. Additional research with older women and ethnically diverse populations is needed. PURPOSE To determine the relationship between sedentary time and mortality in a prospective cohort of ethnically diverse women. METHODS 92,234 women aged 50–79 years at baseline who participated in the Women's Health Initiative Observational Study were the subjects for this study. Self‐reported daily sedentary behavior was assessed by questionnaire and examined by time quartiles in hours: Q1<6; Q2=6–8; Q3>;8–11; Q4>;11. Mortality risk was examined using Cox proportional hazard models adjusting for potential confounders. Models were stratified by age, race/ethnicity, body mass index, physical activity, and physical function to examine possible effect modification. RESULTS The follow‐up period was 12 years. In multivariate analysis, greater sedentary time (Q1 versus Q4) was associated with increased risk of all‐cause mortality (HR=1.12; 95% CI: 1.05– 1.19), and a linear trend for mortality due to cancer, CHD, and CVD (all p<0.05). Black women in Q4 had a 41% increased death risk compared to women in Q1 (HR=1.41, 95% CI: 1.16–1.71). CONCLUSION There was a modest dose‐response relationship between greater sedentary time and mortality risk after controlling for multiple confounders. Research support: T32AG027677; K01HL108807