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Korean pine nut oil attenuated hepatic TG accumulation in high‐fat diet‐induced obese mice
Author(s) -
Park Soyoung,
Shin Sunhye,
Lim Yeseo,
Shin Jae Hoon,
Seong Je Kyung,
Han Sung Nim
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1067.2
Subject(s) - medicine , endocrinology , steatosis , adipose tissue , corn oil , white adipose tissue , lipid metabolism , chemistry , obesity
Korean pine nut oil (PNO) has been reported to have some influence on weight gain and lipid metabolism. We examined whether PNO replacement in high‐fat diet (HFD) can ameliorate HFD‐induced hepatic steatosis compared to soybean oil (SBO). Five‐wk‐old C57BL mice were fed control diets containing 10% energy fat from PNO or SBO (PC, SC) or HFD with 45% energy fat from 10% PNO or SBO and 35% lard (PHFD, SHFD) for 12 wks. Mice in PHFD group gained less body weight (10% less, P = 0.02) and had less white adipose tissue (18% less, P = 0.03) compared to those in SHFD group without significant food intake reduction. Hepatic TG levels tended to be greater in mice fed HFD ( P = 0.08) than those fed the control diets. PHFD group had significantly lower hepatic TG level than SHFD group ( P = 0.001). Overall, PNO upregulated hepatic Acadl mRNA expression ( P = 0.05). Expression of hepatic Pparg mRNA was downregulated in PC group compared to SC group ( P = 0.003). Protein expression of SIRT3 in white adipose tissue was downregulated in SHFD group ( P < 0.001) and was restored in PHFD group to the level of control lean mice ( P = 0.003). In conclusion, PNO consumption resulted in less body fat accumulation and attenuated hepatic steatosis in HFD‐induced obesity, which seemed to be a result of caloric restriction‐mimetic response despite no significant change in food intake. Supported by the grant from National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (Grant no. 20110027052)