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Serum levels of coenzyme Q10, tocopherols, and C‐reactive protein in adolescent girls and premenopausal women
Author(s) -
Chai Weiwen,
Novotny Rachel,
Cooney Robert V,
Maskarinec Gertraud,
Franke Adrian A,
Le Marchand Loic
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1060.11
Subject(s) - coenzyme q10 , body mass index , medicine , c reactive protein , endocrinology , physiology , inflammation
Objective Given the importance of anti‐oxidant dietary compounds for chronic disease prevention, we examined the differences in serum levels of Coenzyme Q10 (CoQ10), α‐tocopherol (α‐Toc), γ‐tocopherol (γ‐Toc), and C‐reactive protein (CRP) between adolescent girls and premenopausal women. Methods Baseline body mass index (BMI) and serum levels of CoQ10, α‐Toc, γ‐Toc, and CRP from 207 adolescent girls (13 to 19 yr) were compared with those from 183 premenopausal women (34 to 47 yr) by t‐test. Associations of age and BMI with serum biomarkers were assessed using multiple regression. Results Adolescent girls had significantly lower mean BMI and serum CoQ10, α‐Toc, γ‐Toc, and CRP levels than premenopausal women (BMI: 22.1 vs. 26.1 kg/m 2 , P <0.0001; CoQ10: 376 vs. 544 ng/mL, P<0.0001; α‐Toc: 6.9 vs. 13.5 μg/mL, P<0.0001; γ‐Toc: 1.28 vs. 1.69 μg/mL, P<0.0001; CRP: 1.29 vs. 2.13 mg/L, P<0.0001). The differences in CoQ10, α‐Toc, and γ‐Toc remained after adjusting for BMI. CRP and γ‐Toc were significantly and positively associated with BMI in both age groups. Conclusions Lower serum CoQ10, α‐Toc, γ‐Toc, and CRP levels observed in the adolescent girls relative to premenopausal women suggest that adolescent girls may have reduced need for circulating antioxidants as a consequence of their lower inflammation status as indicated by the lower CRP values. This research was supported by Department of Defense Grant BC032028 and National Institutes of Health grants R03CA130061 and S10RR020890.