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Effect of dairy intake on bone mineral density (BMD) is only beneficial with higher vitamin D (VitD) intakes: the Framingham Original Cohort
Author(s) -
Sahni Shivani,
Tucker Katherine L.,
Kiel Douglas P.,
Quach Lien,
Casey Virginia,
Hannan Marian T.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.106.5
Subject(s) - medicine , bone mineral , cohort , framingham heart study , femoral neck , zoology , osteoporosis , framingham risk score , endocrinology , disease , biology
Objective To evaluate associations of milk, yogurt, cheese, cream & total dairy intakes with 4y% change in BMD at femoral neck‐FN, trochanter‐TR & lumbar spine‐LS in the Framingham Cohort; also whether VitD intake modified associations. Methods 802 participants had valid FFQ & BMD (1988–89, g/cm 2 ); while 597 had follow‐up BMD (1992–93). Multivariable linear regression estimated adjusted β‐ coefficients & P values. Analyses were then split by VitD intake (lower quartiles: Q1–Q3 vs highest: Q4) & by VitD supplement use (Y/N). Results Mean age of 77y±5, milk intake of 5.9±6.5 serv/wk & VitD intake of 333±285 IU/d. No relations were seen for dairy intakes & % change in any BMD ( P range: 0.26–0.91). For Q4 of VitD intake, higher milk & total dairy intakes were protective against TR‐BMD loss (Table). While in Q1–Q3, total dairy was linked with TR‐BMD loss. VitD supplement users showed similar results. Cream intake was related with FN‐BMD loss but no relations were seen in supplement non‐users or other BMD sites. Conclusions We found milk & dairy intake to protect against TR‐BMD loss in Q4 of VitD intake. VitD supplement users (not non‐users) showed similar results. The relation of dairy intake with BMD appears dependent on VitD intake. Funding support: NIH AR # 053205; AR/AG41398, Framingham Heart Study (N01‐HC‐25195) & General Mills Bell Institute of Health and Nutrition