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Prospective associations of biomarkers of glucose metabolism and obesity‐related cancers in the Framingham Heart Study (1971–2008)
Author(s) -
Parekh Niyati,
Lin Yong,
Vadiveloo Maya,
Hayes Richard,
LuYao Grace,
Lin Yong
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.106.4
Subject(s) - medicine , hazard ratio , glycemic , obesity , framingham heart study , incidence (geometry) , prospective cohort study , european prospective investigation into cancer and nutrition , cancer , endocrinology , diabetes mellitus , framingham risk score , confidence interval , insulin , disease , physics , optics
Obesity‐induced aberrations in glucose metabolism are associated with cancer risk. We investigated prospective associations of hyperglycemia with incidence of cancers associated with obesity, in the Framingham Heart Study Offsprings (n=4615; n events=787; 1971–2008; mean age 66.8y in 2008). Serum insulin and glucose were estimated from fasting blood; lifestyle and demographic information was obtained from in‐person interviews. Time‐dependant survival analyses were used to compute hazard ratios (HR) and 95% confidence interval (CI) of cancer incidence, using SAS. After adjusting for age, sex, smoking status, alcohol and physical activity, hyperglycemia (>;110 mg/dl) was associated with 27% increased risk of overall obesity‐related cancer incidence (HR:1.27; CI:1.1–1.5). Risk was 47% (CI:1.1–1.9) and 54% (CI:1.1–2.1) higher among persons with hyperinsulinemia and poor long‐term glycemic control measured by hemoglobin A1c, respectively for tertiles 3 vs 1. Associations were stronger in “ever” smokers (HR:1.41; CI: 1.1–1.8). In gender stratified analyses, associations were stronger among females. Hyperglycemia for 10–20y and 20+y increased risk by 44% (CI: 1.1–1.6) and 86% (CI: 1.5–2.2) of overall obesity‐related cancers, respectively. Hyperglycemia, particularly poor long‐term glycemic control, is a ‘high‐risk’ condition for obesity‐related cancer incidence.