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Vitamin D deficiency in cord plasma from multiethnic subjects living in the tropics
Author(s) -
Halm Brunhild M,
Lai Jennifer F,
Pagano Ian,
Cooney William,
Soon Reni A,
Franke Adrian A
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1058.8
Subject(s) - medicine , vitamin d and neurology , vitamin d deficiency , cord blood , pregnancy , vitamin , cord , physiology , surgery , biology , genetics
Vitamin D deficiency is common in high latitude areas and in dark skin people. However, nothing is known about vitamin D in cord blood from multiethnic subjects living in the tropics. We determined the prevalence of vitamin D deficiency in cord blood from multiethnic individuals in Hawai'i. 25‐hydroxyvitamin D (25(OH)D) levels were quantified by ELISA in 100 cord plasmas from apparently healthy full term newborns. Overall, 25(OH)D levels ranged from 9.1 to 68.3 ng/mL; 28% were deficient (<20 ng/mL) and 50% were insufficient (20–30 ng/mL). Mean levels (ng/mL) were highest in Caucasians (30.5) followed by Asians (25.1), Hispanics (21.5), Pacific Islanders (20.0), and African Americans (19.6). Differences among groups were significant (p=0.008). Summer versus winter samples were higher overall (p=0.001) and among Asians (p=0.0003). Seasonal changes were correlated with sun irradiance overall (r=0.43, p=0.0001), among Caucasians (r=0.45, p=0.05), and among Asians (r=0.45, p=0.0001). Our results suggest that prenatal supplement recommendations of 400 IU vitamin D/day does not protect against vitamin D deficiency, even in subjects living in the tropics. Our results emphasizes the need for regular 25(OH)D monitoring, particularly during pregnancy and lactation, in dark skin people, and during winter months. Supported by grants from NCI (P30 CA71789), NCRR (S10 RR020890) and RMATRIX award (U54 RR026136).