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Inrauterine growth retardation results in altered metabolism and elevated preadipocyte proliferation in pigs
Author(s) -
Ajuwon Kolapo M
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1058.6
Subject(s) - adipose tissue , endocrinology , medicine , small for gestational age , adipogenesis , growth retardation , beta oxidation , obesity , weight gain , biology , chemistry , metabolism , body weight , fetus , pregnancy , genetics
The pig is a natural animal model for the study of intrauterine growth retardation because it is a polytocous animal. Being born small for gestational age (SGA) is associated with higher susceptibility to obesity development later in life. The biological explanation for this increased risk for obesity in SGA animals is not well defined. We determined the proliferative capacity of preadipocytes isolated from the subcutaneous adipose tissue of SGA or control neonatal pigs (less than 1 week old). Higher (approx. 70% increase) preadipocyte proliferation was observed in the SGA vs. control (P<0.05). Adipose tissue and preadipocytes from SGA pigs also have reduced PPARγand UCP‐2 expression. Preadipocytes from SGA animals have limited capacity for differentiation vs. control animals. Reduced UCP‐2 expression in SGA animals also suggest impaired fatty acid oxidation compared to control animals. The reduced capacity for differentiation in SGA animals may be linked to their reduced capacity to oxidize lipids. Strategies that upregulate fatty acid oxidation may help reduce preadipocyte proliferation and prevent future obesity development in SGA animals.