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Iron status is associated with auditory brainstem response measures in newborns
Author(s) -
Lee Sunmin,
Guillet Ronnie,
Orlando Mark,
Cooper Elizabeth,
Pressman Eva,
Queenan Ruth Anne,
O'Brien Kimberly O
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1058.1
Subject(s) - medicine , quartile , gestational age , brainstem , in utero , pediatrics , audiology , pregnancy , fetus , biology , confidence interval , genetics
Iron (Fe) deficiency in utero may impact auditory nerve myelination. Auditory brainstem response (ABR) provides a noninvasive means of assessing auditory neural maturation. To assess relationships between neonatal Fe status and auditory neural outcomes, ABR measures were evaluated in 112 neonates born to pregnant adolescents (16.9 ± 1.0 y). Neonatal Fe status was assessed using cord blood obtained at birth (39.9 ± 1.4 wks): 26% of newborns were anemic (Hb <13.5 g/dL), and the neonatal serum ferritin (SF) and total body Fe (TBI) were 152.9 ± 120.7 μg/L, 8.1 ± 3.5 mg/kg respectively. Higher neonatal SF and TBI were associated with shorter absolute wave I latencies ( p <0.01), and neonates with SF and TBI measures in the lowest quartile had significantly prolonged absolute wave I latency compared to those in the highest quartiles (1.75 ± 0.18 vs. 1.62 ± 0.15 msec, p =0.002 for SF; 1.76 ± 0.18 vs. 1.62 ± 0.14 msec, p =0.007 for TBI). All analyses were controlled for gestational age, birth weight, head circumference and infant sex. Our findings suggest that there appears to be an association between limited Fe stores in neonates with prolonged neural transmission time. Increased attention on optimizing Fe status among newborns is warranted. Supported by USDA 2005–35200; 2008–01857. Grant Funding Source : USDA 2005–35200; 2008–01857.