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Effect of the glutathione s‐transferase (GST) M1 and Tl polymorphism on the blood pressure, lipid profiles, and the blood glucose of Korean subclinical hypertensive patients after kale juice supplementation
Author(s) -
Kang MyungHee,
Han JeongHwa,
Lee HyeJin,
Kim Tae Seok
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1057.6
Subject(s) - blood pressure , genotype , glutathione s transferase , medicine , subclinical infection , endocrinology , lipid profile , glutathione , biology , cholesterol , enzyme , biochemistry , gene
Glutathione s‐transferase (GST) forms a multigene family of phase II detoxification enzymes which are involved in detoxification of reactive oxygen species. In this study, we examined whether daily supplementation of kale juice could modulate the blood pressure, levels of lipid profiles and the blood glucose, and whether this modulation could be affected by the GSTM1 and T1 polymorphisms. 84 subclinical hypertensive patients showing the systolic blood pressure (BP) over 130 mmHg or the diastolic BP over 85 mmHg received 300 ml/day of kale juice for 6 weeks, and blood samples were drawn before and after 6 weeks. Blood pressure significantly decreased in all GST genotypes after kale juice supplementation. Plasma glucose level decreased only in the GSTM1‐wild genotype, and plasma lipid profiles showed no difference in both GSTM1‐null and GSTM1‐wild genotypes. However, plasma HDL‐C was increased and LDL‐C was decreased in GSTT1‐wild type, while the blood glucose decreased in GSTT1‐ null genotype. Our findings suggest that the supplementation of kale juice might improve lipid profile in GSTT1‐wild genotype and decrease the blood glucose in the GSTM1‐wild or GSTT1‐null genotypes. (This research was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF) under the sponsorship of the Ministry of Education, Science and Technology (2012–0001682)).