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A randomized controlled trial of genetic information on dietary intake
Author(s) -
Nielsen Daiva,
ElSohemy Ahmed
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1057.16
Subject(s) - randomized controlled trial , medicine , allele , genotype , food frequency questionnaire , intervention (counseling) , biology , gene , genetics , psychiatry
Personal genetic information has become obtainable as a result of commercial genetic tests, but its effect on dietary change is not clear. We compared the effects of providing DNA‐based dietary advice with general recommendations on dietary intake using a randomized trial. Subjects aged 20–35 years (n=102) completed a baseline food frequency questionnaire (FFQ) and were randomized to an intervention (I) or control (C) group. Subjects in the intervention group were genotyped for the angiotensin‐I converting enzyme ( ACE ) gene, which has been associated with salt‐sensitive hypertension, and were given personalized advice for sodium intake based on their ACE genotype. The control group was given a general recommendation for sodium intake without genetic information. A second FFQ was collected 3 months later. A significant reduction in sodium intake was observed in subjects in the intervention group who were informed that they carried the risk allele for ACE when compared to the control group (−174.9±89.1 mg/day [I] vs. 225.5±123.5 mg/day [C]; p = 0.008). No difference was observed between subjects who were informed that they did not carry the risk allele and controls (111.2±145.0 mg/day [I] vs. 225.5±123.5 mg/day [C]; p = 0.48). The results suggest that personalized advice based on genetic information may be superior to general advice in motivating individuals to adopt dietary changes. Grant Funding Source : Advanced Foods and Materials Network