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Compound Seropositivity of neutralizing antibodies against Adipogenic Adenoviruses (ADV36+ and ADV 37+): no additive effect on overweight‐obesity and on Insulin Resistance (IRHOMA). The microbiome across the obesity and into the liver
Author(s) -
Trovato Guglielmo M.,
Catalano Daniela,
Martines G. Fabio,
Trovato Francesca M.,
Garozzo Adriana,
Pirri Clara,
Tonzuso Antonia
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1056.4
Subject(s) - medicine , obesity , insulin resistance , overweight , endocrinology , gastroenterology
A greater hazard of obesity and Insulin Resistance is associated with ADV36 adenovirus seropositivity (ADV36+). Human ADV37 has steatogenic liver effects in humans, but adipogenic effect only in animals: ADV37+patients do not show greater prevalence of obesity vs. ADV37/ADV36 seronegative subjects. Aim to investigate if compound ADV36/ADV37 seropositivity exerts a different effect on overweight‐obesity and IR vs. seronegative subjects and vs. ADV36‐ADV37 single seropositivity. 430 patients were studied, m 157, f 273, age 47.99 ± 15.50 years, BMI 28.14 ± 6.29. Dietary profile was assessed by Adherence to Mediterranean Diet Score (AMDS). Greater BMI (29.74 ± 7.21 vs. 26.47 ± 5.32;p: 0.004) and no difference for HOMA (2.42 ± 1.38 VS 2.28 ± 1.38; p: 0.591) are observed in ADV36+ subjects vs. ADV37+. Compound ADV36+/ADV37+ vs. ADV37+ lone seropositivity has greater BMI: 29.42 ± 6.13 vs. 26.47 ± 5.32; p: 0.001 and greater HOMA: 2.94 ± 2.31 vs. 2.28 ± 1.38; p: 0.029, exactly as the compound seropositivity vs. totally seronegative subjects: BMI: 29.42 ± 6.13 vs. 26.41 ± 5.99; p: 0.0001; HOMA: 2.94 ± 2.31 vs. 2.07 ± 1.39; p: 0.0001; no difference for compound seropositivity ADV36+/ADV37+ vs. ADV36+ lone group. No difference of AMDS was observed between any group. Conclusion ADV36+ and ADV37+ compound seropositivity, independently by difference of nutritional profile, has no additive effect for obesity and insulin resistance.