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Maternal DHA supplementation during pregnancy and plasma lipids and glucose levels in offspring at age 4y: follow‐up of a randomized controlled trial
Author(s) -
GutierrezGomez Yareni Yunuen,
Ramakrishnan Usha,
Stein Aryeh D.,
Martorell Reynaldo,
AguilarSalinas Carlos,
Romieu Isabell,
Rivera Juan A.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1055.9
Subject(s) - offspring , medicine , docosahexaenoic acid , endocrinology , pregnancy , placebo , insulin , gestation , fatty acid , polyunsaturated fatty acid , biology , biochemistry , genetics , alternative medicine , pathology
Little is known about the effects of prenatal docosahexaenoic acid (DHA) supplementation on offspring lipid and glucose metabolism. We investigated the effect of maternal DHA supplementation during pregnancy on offspring plasma lipid and glucose levels at age 4 y. In a double‐blind, randomized, controlled trial conducted in Mexico, pregnant women were supplemented daily with 400 mg DHA or placebo from 18–22 wk gestation to parturition. Offspring of the women who participated in this study are being followed; at age 4 y non‐fasting blood samples, were obtained from 524 children (53.9% of the birth cohort). We assessed total cholesterol (TC; mean ±SD 157.9 ±25.3mg/dl); LDL‐C (83.0 ±21.9mg/dl); HDL‐C (51.7 ±10.1mg/dl); Apo B (76.9 ±15.2mg/dl); triglycerides (122.1 ±67.4mg/dl); glucose (93.7 ±10.9mg/dl) and insulin (9.7 ±11.2μU/ml). Between‐group differences (DHA ‐ placebo), adjusted for maternal height and time since last food intake, were: TC, 1.73 mg/dl (95% CI −2.63, 6.09); LDL‐C, 1.62 mg/dl (0.24, 1.42); HDL‐C, 0.66 mg/dl (−1.07, 2.39); Apo B, −0.15 mg/dl (−2.78, 2.48); triglycerides −0.15 mg/dl (−11.50, 11.21); glucose −0.99 mg/dl (−2.86, 0.88); insulin −0.18 μU/ml (− 2.08, 1.7). In this study, prenatal DHA supplementation did not impact on lipids and glucose markers in early childhood. Funded by NIH ( HD043099 )