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Iron and diabetes risk among Filipino women
Author(s) -
Feranil Alan,
Lee Nanette,
Bas Isabelita,
Largado Fe,
Adair Linda
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1055.28
Subject(s) - medicine , diabetes mellitus , quartile , confounding , impaired fasting glucose , odds ratio , endocrinology , physiology , environmental health , insulin resistance , impaired glucose tolerance , confidence interval
Some studies suggest that increased iron intake may lead to diabetes risk possibly thru oxidative stress, inflammation, free fatty acid oxidation, insulin extraction and secretion. But, this has not yet been established in less developed countries where iron deficiency is likely to occur. We examined the association of iron intake with impaired fasting glucose/diabetes mellitus (IFG/DM: FG>;=110 mg/dL) using data from 1,871 women (ages 35–68 yr) from the Cebu Longitudinal Health and Nutrition Survey in 2005. About 9% of women had IFG/DM. On average, women consumed 11.25±7.04 mg of iron daily. Logistic regression analyses adjusted for current BMI, age, total energy intake and other confounders showed that the odds of having IFG/DM increased with iron intake. Compared to the lowest quartile of iron intake, those in the highest quartile were 78% more likely to have IFG/DM [OR(95% CI): 1.78 (1.01–3.12)]. Results of this study suggest the need to further examine the link between iron intake and diabetes risk in less developed countries like the Philippines where iron deficiency anemia is still prevalent but diabetes has also become one of the major causes of mortality and morbidity. R01TW008288