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Bone Turnover Markers Detect Different Treatment Effects Within Six Weeks
Author(s) -
Gertz Erik Randolph,
Rogers Tara,
Demmer Elieke,
Cheng Deanna,
Villegas Anna,
Garrod Marge,
Van Loan Marta
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1053.7
Subject(s) - bone resorption , urine , excretion , calcium , washout , zoology , vitamin d and neurology , n terminal telopeptide , alkaline phosphatase , chemistry , bone remodeling , medicine , urinary system , resorption , endocrinology , biology , biochemistry , osteocalcin , enzyme
Our objective was to compare changes in bone turnover markers in response to different treatments. Ten postmenopausal women consumed calcium & vitamin D tablets (1200mg & 400IU/day) and 4 servings of dairy/d in random order. Interventions lasted six weeks separated by a 6 week washout. A 24‐hour urine was collected 1x/wk for 6 weeks. Serum was collected at the start and end of each intervention. Bone alkaline phosphatase (BAP) and C‐terminal telopeptide of Type I collagen (CTx) were measured in serum by ELISA. Urinary Ca, Mg, P, K, and Na were quantified by inductively coupled plasma atomic emission spectrophotometry (ICP‐AES). Urinary excretion of Ca, Mg and Na were not significantly different between treatment interventions. However, excretion of P and K were significantly higher (p<0.05, two‐way ANOVA) with dairy intervention possibly reflecting the mineral content of dairy foods. Percent change in BAP for treatment groups or washout were not different. However, there were significant differences between washout and both treatment groups for CTx (p<0.05, 2 way ANOVA).Our results indicate that either calcium & vitamin D supplements or dairy foods may be protective by reducing bone resorption. Discontinuation appears to result in increased resorption. Funding was provided by the Dairy Research Institute, Dairy Council of California, and the USDA‐ARS‐WHNRC.