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Association of Genetic Polymorphism of Peroxisome Proliferator‐Activated Receptor‐Gamma Gene and Polycystic Ovary Syndrome
Author(s) -
Hemimi Neveen Salah Eldine,
Shaafie Ishtiyaq Ahmad,
Alshawa Haya Husni A
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1012.1
Subject(s) - polycystic ovary , genotype , peroxisome proliferator activated receptor , endocrinology , insulin resistance , medicine , peroxisome proliferator activated receptor gamma , biology , obesity , gene , receptor , genetics
Background Peroxisome proliferative‐ activated receptor gamma (PPARs) is a nuclear receptor which controls transcription of genes involved in free fatty acid uptake and lipogenesis, and is essential for differention and survival of adipocytes. Aim To investigate the association of Pro12Ala polymorphism in PPAR gamma gene with polycystic ovary syndrome (PCOS) and its related metabolic disorders. Material and Method The study consisted of 50 women diagnosed with PCOS and 96 healthy women as a control group. Individuals were genotyped for Pro12Ala genetic polymorphism of PPAR gamma by using polymerase chain reaction‐ restriction fragment length polymorphism. Statistical analysis was done by SPSS program. Results Frequency of Pro12/Pro12 and Pro12/Ala12 genotypes were 86% and 14% in PCOS group compared to 77.1% and 22.9% in control group. The carriers of Pro12/Pro12 genotype exhibited a significant greater risk for PCOS compared to carriers of Pro12/Ala12 genotype (OR= 1.8, 95%CI= 0.7–4.6). Furthermore they were at higher risk of different metabolic disorders such as obesity, insulin resistance and diabetes mellitus. Conclusion Pro12/Pro12 genotype is a risk factor for PCOS and its related metabolic disorders. Source of Fund: Dubai Medical College for girls.