Premium
Aerobic exercise training during pregnancy improves mitochondrial function in human placenta
Author(s) -
RamírezVélez Robinson
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1011.2
Subject(s) - placenta , mitochondrion , aerobic exercise , pregnancy , medicine , andrology , gestation , physiology , endocrinology , biology , fetus , biochemistry , genetics
This was a randomized, controlled clinical trial of 20 healthy primigravid women between 16 and 20 weeks’ gestation. The pregnant women who were assigned to the exercise group received a supervised aerobic exercise program of 60 min sessions, three times a week. The effect of aerobic exercise training on mitochondrial function from human placenta was studied during the second half of pregnancy. Respiratory control showed a tendency to diminish in placental mitochondria from exercised women, as compared with control subjects. Mitochondrial membrane potential was not significantly affected by training. Mitochondrial O2‐levels and H2O2 production rate were decreased by 6% and 26% respectively in placental mitochondria from exercised women, as compared with control subjects (p<0.05). Activity of complex I‐III of the mitochondrial respiratory chain was increased by 29% in human placental mitochondria from exercised women, as compared with control subjects (p<0.05). Also, significant increases of 45% and 21%, (p<0.05) were observed in complexes II‐III and in complex IV respectively in placental mitochondria from exercised women, as compared with the controls. Aerobic training improves mitochondrial function in human placenta by increasing mitochondrial respiratory complexes activity and decreasing O2‐ and H2O2 production.