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Is There Any Relationship Between CASP‐8 D302H Gene Variation and Colorectal Cancer Risk
Author(s) -
Pence Sadrettin,
Cacina Canan,
Arikan Soykan,
Turan Saime,
Pence Esad,
Genc Feyza,
Yaylim Ilhan
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb95
Subject(s) - colorectal cancer , genotype , casp , gene , carcinogenesis , biology , polymerase chain reaction , medicine , oncology , cancer research , cancer , genetics , biochemistry , protein structure prediction , protein structure
Caspase‐8(CASP‐8) is a key regulator of apoptosis, an essential defense mechanism against hyperproliferation and tumorigenesis. Polymorphisms in CASP8 gene have been reported to influence cancer risk. The present study was designed to investigate the role of CASP‐8 D302H gene polymorphism in the colorectal cancer development. CASP‐8 D302H genotypes were determined by using polymerase chain reaction‐restriction fragment lenght polymorphism (PCR‐RFLP) analysis. A total of 80 patients with colorectal cancer and 127 control individuals were enrolled in the current study. There were no significant differences in the distribution of CASP‐8 D302H genotypes between colorectal cancer patients and controls The carrying of CASP‐8 D302H GG/CC homozygous genotypes were increased in patients compared to control group and this difference was statistically significant (p:0.023; 1.303(1.045–1.626). These results suggest that D302H polymorphism in CASP‐8 gene may be associated with increased risk of colorectal cancer.