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Endogenous hydrogen sulfide is involved in the brain's control of arterial blood pressure
Author(s) -
Sikora Mariusz,
Ufnal Marcin
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb796
Subject(s) - blood pressure , bradycardia , heart rate , hemodynamics , medicine , mean arterial pressure , endogeny , anesthesia , cystathionine beta synthase , cardiology , chemistry , biochemistry , amino acid , methionine
Hydrogen sulfide (H2S) has recently been found to play an important role in the regulation of the circulatory system, however, its effect on the brain's control of arterial blood pressure has not been established yet. In the study we investigated the hemodynamic effects of intracerebroventricular (icv) infusions of S‐adenosyl‐L‐metionine (SAM), an activator of cystathionine betasynthase which produces H2S in the brain. We preformed experiments on freely moving, male, Wistar Kyoto rats. Mean arterial blood pressure (MAP) and heart rate (HR) were recorded at baseline and during icv infusions of SAM. The infusions produced a dose dependent, biphasic response, i.e. moderate hypotension and bradycardia lasting 10–15 min, which were followed by long‐lasting significant increases in MAP and HR. These findings suggest that endogenous H2S in the brain is involved in the neurogenic control of blood pressure, and that the effects of H2S may depend on its concentration and/or the site of its action in the brain. This work was supported by the National Science Center, grant 3G29 and Medical University of Warsaw, grant 1MA/PM11/11.