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The role of myostatin on skeletal muscle energy metabolism during rest and exercise
Author(s) -
Reisz-Porszasz Suzanne,
Abraham Andrea,
Kovanecz Istvan,
Lew Henry,
Constantinescu Silvana,
Porszasz Janos
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb788
Subject(s) - medicine , endocrinology , myostatin , skeletal muscle , chemistry , metabolism , treadmill , biology
Myostatin (Mst) regulates skeletal muscle mass and adipogenesis, but its role in regulating metabolism and physical performance is unknown. We investigated three mouse models: Mst overexpressing transgenic [TG]; Mst knock‐out [KO]; wild type [WT]. Male (1 yr) mice were fed a regular (R), low carb (LC), high carb (HC) or high fat (HF) diet for 6 wks. Maximal (MS) and critical (CS) running speed and ‘work capacity’ (W’) were determined using a treadmill at 5% incline. Results were allometrically scaled for body mass. Calorific intake was not different among diets. Compared to R, body mass was lower all animals in LC (5–8%; P<0.05), but in HC was 9% lower only in KO (P<0.05). During HF body mass was 41% greater in TG than WT (P<0.05). MS was faster among TG animals, especially in LC diet (TG=50±2; WT=40±1; KO=35±1 m/min; P<0.05), and was slower in KO. Also, CS was slower in TG than WT (P<0.05), but only during HC and HF diets. W’ was independent of diet but significantly greater in TG (TG=41±10 m; WT=25±5 m; KO=18±5; P=0.012). The results are consistent with a metabolic regulatory role of Mst, where overexpression results in a greater reliance on â‐oxidation and a reduced glycogenolytic rate. Supported by U54RR022776, SC1GM089648‐01A1.