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Cardiac glycogen influences protective responses of newly born rats to hypoxia
Author(s) -
Fewell James Edwin,
Zhang Chunfen
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb773
Subject(s) - glycogen , hypoxia (environmental) , apnea , medicine , endocrinology , cardiac function curve , anesthesia , chemistry , heart failure , oxygen , organic chemistry
Failure to autoresuscitate from apnea by gasping has been suggested to play a role in sudden infant death. Little is known, however, about the factors that influence the ability of gasping to sustain life during acute hypoxia in the newborn. The present experiments were carried out on newly born rat pups to investigate the influence of cardiac glycogen on the time to last gasp (TLG) during a single hypoxic exposure, and on the ability to autoresuscitate (AR) from primary apnea during repeated hypoxic exposures. Heart glycogen was decreased in one to two day‐old pups by isoproterenol‐induced transient tachycardia. Both the TLG (Veh 2318±239s vs ISO 1990±315s; n=22) and the number of successful AR (Veh 29±12 vs ISO 20±12; n = 10) were significantly decreased (p<0.05) in newly born rat pups which had decreased cardiac glycogen. Thus, our data provide evidence that cardiac glycogen supports cardiac function and plays a role in sustaining life during hypoxia in newly born rat pups.