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Curcumin consumption reduces gut microbial diversity among patients with colorectal adenomas
Author(s) -
McLauchlin April,
Araujo-Perez Felix,
McCoy Nikki,
Smith Kevin,
Sandler Bob,
Asher Gary,
Keku Temitope
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb768
Subject(s) - curcumin , eubacterium , bifidobacterium , bacteroides , colorectal adenoma , dysbiosis , faecalibacterium prausnitzii , bacteroides fragilis , butyrate , gut flora , lactobacillus , microbiome , biology , microbiology and biotechnology , gastroenterology , medicine , feces , colorectal cancer , bacteria , pharmacology , immunology , food science , cancer , bioinformatics , antibiotics , fermentation , genetics
Preclinical studies suggest a role for curcumin in prevention of CRC, but there are few human studies to confirm its effects. Much of our diet is metabolized by gut bacteria, and bacterial dysbiosis is associated with colorectal adenomas, CRC precursors. We hypothesized that curcumin alters the gut microbiota. We assessed the composition of mucosally‐adherent bacteria in participants with (21 case) and without adenoma (14 control) before and after curcumin intake (4g/day for 4 weeks). Non‐prepped, rectal mucosal biopsies were used to assess bacterial profiles by terminal restriction fragment length polymorphism as well as qPCR of common gut bacterial groups. Bacterial diversity was reduced at follow‐up compared to baseline (p= 0.03). We observed reduction in copy numbers of all bacterial groups among cases following curcumin intervention; 47% E. coli, 30.7% Clostridium, 33% Bacteroides, 26% Eubacterium, 22% Bifidobacterium, and 20% Lactobacillus. Curcumin administration can reduce the adherent bacterial diversity in patients with colonic adenomas. Further understanding of the relationship between bacterial diversity and CRC may support a role for the chemopreventive properties of curcumin. Funding support by NIH P30 DK 034987, R01 CA136887 , R01 CA044684 , P50CA106991 .