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Effects of some anti‐diabetic drags on the utilization of carbohydrates in fish
Author(s) -
Takase Kiyomi
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb722
Subject(s) - medicine , endocrinology , insulin , rainbow trout , chemistry , tolbutamide , insulin resistance , glucose uptake , carbohydrate metabolism , diabetes mellitus , fish <actinopterygii> , biology , fishery
Most teleost fish are characterized by a limited efficiency to use carbohydrates. The poor metabolic glucose utilization of fish suggests to be related to not only an insufficient secretion of insulin, but also a high insulin resistance state. The purpose of this study is to investigate the effects of some anti‐diabetic drags on the utilization of carbohydrates in fish. Goldfish and rainbow trout were used in this experiment. Fish were administrated orally tolbutamide (Tr), chlorpropamide (Ch), aguripuchin (Ag), pioglitazone (Pi) and metformin (Mt). After three weeks, the rate of 2‐deoxy‐D‐glucose (2DG) uptake in skeletal muscle and changes in blood glucose and insulin concentrations in the fish administered glucose intraperitoneally (glucose tolerance test: GTT) were investigated. In goldfish administered Tr or Ch, no significant change in GTT was observed on the rate of 2DG uptake in muscle and on plasma glucose and insulin levels. Ag enhanced insulin secretion during GTT and promoted to the recovery of blood glucose. Pi and Mt increased the rate of 2DG and promoted the recovery of blood glucose. On the other hand, in rainbow trout, each Tr, Ch, Ag, Pi and Mt was improved hyperglycaemia. These results suggest that most fish begins efficiently using the carbohydrates by (1) the enhancement of the rate of insulin synthesis in beta cells and (2) the improvement of the insulin sensitivity of muscle.