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Stronger vasoconstrictor response to aspirate from patients undergoing stent implantation into native coronary arteries than into saphenous vein grafts
Author(s) -
Kleinbongard Petra,
Baars Theodor,
Möhlenkamp Stefan,
Konorza Thomas,
Kahlert Philipp,
Erbel Raimund,
Heusch Gerd
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb633
Subject(s) - coronary arteries , medicine , vasoconstriction , cardiology , mesenteric arteries , myograph , stent , vasodilation , artery
Background Stent implantation into atherosclerotic coronary arteries releases particulate debris and soluble substances which contribute to impaired microvascular perfusion. Methods Using a distal protection/aspiration device, arterial blood was retrieved during stent implantation in 19 patients with a stenosis in native coronary arteries (NA) and in 20 patients with a saphenous vein graft (SVG) stenosis. The constrictor response of rat coronary and mesenteric arteries to aspirate was quantified in a myograph as isometric force development (mN). Results At 80 mmHg, the diameter was 250±28 μm for coronary and 186±16 μm for mesenteric arteries. The KCl (120mM) ‐ induced maximal vasoconstriction was comparable for coronary and mesenteric arteries (6.1±2.3 mN vs. 7.1±1.4 mN; NS). The vasoconstriction provoked by aspirate was greater in coronary than in mesenteric arteries. Aspirate released during stent implantation into NA induced a stronger vasoconstriction than that into SVG (coronary: NA 6.9±0.8*†, SVG 5.2±0.7†, mesenteric: NA 5.6±0.9*, SVG 4.2±0.5 mN; *p<0.05 NA vs. SVG, †p<0.05 coronary vs. mesenteric arteries). Conclusion Human coronary aspirate released during stenting of NA has a stronger vasoconstrictor potential than that from SVG. The vasoconstrictor response to human coronary aspirate is more profound in rat coronary than in mesenteric arteries.