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Influence of exercise on adult hippocampal neurogenic subpopulations and its effects on behaviour
Author(s) -
Gradari Simona,
Pérez-Domper Paloma,
Ortega Sylvia,
Trejo Jose L
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb62
Subject(s) - hippocampal formation , neuroscience , anxiolytic , neurogenesis , cognition , physical exercise , psychology , medicine , anxiety , psychiatry
The therapeutic interest of the beneficial effects of exercise prompted us to analyze those effects influenced by the duration of the training and the time elapsed between training and evaluation. In particular, the differential sensitivity of learning/memory vs emotional behavior, and of distinct subpopulations of immature neurons depending on their age. To this goal, we have carried out a 2 weeks forced exercise paradigm, either immediately before or 2 months before evaluation; we have also employed a novel analysis of multiple birthdating, behavioral assessment and stereology. We found that exercise effects are significant at different times depending on the type of behavior examined: the anxiolytic effects are detectable immediately after training, and also 2 months after exercise, while the pro‐cognitive effects are discrete and appreciable only immediately after training. Exercise affects adult hippocampal neurogenesis inducing an increase in the number of new neurons, but at least one subpopulation of immature neurons correlated negatively with the anxiolytic effect, opposite to the rest of immature neurons. These data show that although the sensitivity of new neurons to physical exercise is similar, its role on the animal's behavior is different. These results provide new evidences for the involvement of new adult‐borne immature neurons in different behavioral tasks, depending on their age.