Premium
Race Affects Arterial and Ventricular Elastance Responses to Endurance Exercise Training
Author(s) -
Lane Abbi Danielle,
Yan Huimin,
Ranadive Sushant M,
Cook Marc D,
Kappus Rebecca M,
Wilund Kenneth,
Woods Jeffrey A,
Fernhall Bo
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb619
Subject(s) - arterial stiffness , cardiology , medicine , pulse wave velocity , pulse pressure , blood pressure , applanation tonometry
The ventricular‐vascular coupling ratio consists of the ratio of arterial load (Ea) to ventricular stiffness (Elv). Blood pressure (BP) and arterial stiffness affect Ea/Elv. African Americans (AA) have higher large artery stiffness and BP compared to Caucasian Americans (CA), but exercise training reduces BP and large artery stiffness. Our purpose was to determine the effects of race on this ratio after 8 weeks of training. We hypothesized a reduction in the ratio due to a reduction in EaI that would be more pronounced in CA versus AA adults. We used applanation tonometry to measure central BP, and central pulse wave velocity (cPWV) to quantify central arterial stiffness and cardiac ultrasonography to determine LV volumes before and after our training period. We used the formulas: Ea=ESP/SV and Elv=ESP/ESV scaled by BSA. AA and CA maintained their pre‐training ratios (p>0.05 for time and interaction effect), but CA did so by augmenting both EaI and ElvI (EaI was 0.76±0.1 and 0.77±0.09 mmHg/ml/m2 pre to post‐training in AA, and went from 0.68±0.09 to 0.75±0.1 mmHg/ml/m2 in CA, p<0.05 for CA; ElvI was unchanged in AA, 1.20±0.11 to 1.22±0.1 mmHg/ml/m2, p>0.05, but increased in CA, 0.99±0.1 to 1.16±0.1 mmHg/ml/m2 p<0.05) despite similar reductions (p<0.05) in SBP in both races. Only AA reduced cPWV after training (p<0.05). We conclude that the training responses of Ea and Elv were different between races.