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Antioxidant activity of a combination of atorvastatin and lycopene in normal Sprague Dawley rats
Author(s) -
Pina Rosa M,
Carmen Caamaño Maria,
Garcia Olga P,
Rosado Jorge Luis
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb594
Subject(s) - lycopene , atorvastatin , catalase , antioxidant , superoxide dismutase , chemistry , pharmacology , biochemistry , medicine
The present study evaluated the effect of atorvastatin and lycopene on the activity of antioxidant enzymes in normal rats. Thirty male Sprague Dawley rats (200 ± 10g) received either 50 mg/kg/d of atorvastatin (AT), 20 mg/kg/d of lycopene (LYC), 50mg/kg/d of atorvastatin + 20mg/kg/d lycopene (AT50+LYC) or 20mg/kg/d of atorvastatin + 20mg/kg/d of lycopene (AT20+LYC). The control group received water; treatments were given by oral intubation during 14 days. All rats were fed with regular rodent chow. Blood samples were taken 24‐h after the last oral intubation for the determination of catalase and superoxide dismutase (SOD) enzyme activities using commercial assay kits. Catalase activity was significantly induced by all treatments by 2.1 to 4.4 fold compared with control (p<0.05). The doses of AT50+LYC and AT20+LYC had the highest effect on catalase induction compared to other treatments (p<0.05). SOD activity was significantly induced with LYC by 1.1‐fold compared to control group (p<0.05). In conclusion, the combination therapy of atorvastatin and lycopene showed a favorable antioxidant activity. The potential benefits on cardiovascular diseases remains to be evaluated. CONACYT