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Functional variants of the cysteinyl leukotriene 1 and cysteinyl leukotriene 2 receptors are associated with atopic asthma
Author(s) -
Thompson Miles Douglas,
Capra Valerie,
Rovati Enrico,
Stankova Jana
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb555
Subject(s) - atopy , asthma , immunology , medicine , phenotype , etiology , genetics , gene , biology
The atopy phenotype is reported to be a risk factor for asthma. Among the many loci that contribute to a genetic predisposition to asthma, the cysteinyl leukotriene receptor 1 (cysLT1) and 2 (cysLT2) genes have been important subjects of study because they are functionally and pharmacologically implicated in the atopy phenotype affecting many asthma subjects. In some populations we have found that the G300S variant of the cysLT1 receptor is associated with atopy. In an earlier association study, the M201V variant of the CysLT2 was implicated in atopic asthma. In this study we identify the statistical association of both the variants with the atopy phenotype. We propose a two hit hypothesis of atopy inheritance that involves the cysLT1 and cyLT2 variants. In vitro analyses are beginning to provide evidence that cysLT1 and cysLT2 interaction within the cell is possible and may represent a mechanism for the etiology of atopy in asthmatic populations.