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Circulating genotypes of influenza virus in India and their correlation with clinical features and metereological factors
Author(s) -
Jain Amita,
Dangee Tanushree,
jain Bhawna,
Singh Kaleshwar Prasad,
Singh Jaiveer,
Singh Ajai,
Dwivedi Mukesh
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb501
Subject(s) - virus , genotype , medicine , pandemic , virology , influenza a virus , human mortality from h5n1 , immunology , veterinary medicine , disease , biology , covid-19 , gene , infectious disease (medical specialty) , biochemistry
The present study was undertaken to investigate the prevalent genotypes of influenza viruses in India and study their correlation with meteorological factors and clinical features. A total of 1175 patients were enrolled and divided into two severity groups; influenza like illness (ILI; 961) and severe acute respiratory illness (SARI; 214). Confirmation of influenza A and B positives was done by one step real‐time RT‐PCR using group specific primers. Influenza A positives were further subtyped into H1, H3 and pandemic H1 and correlated with various environmental factors to determine seasonality. Association of Influenza A and B infection with clinical parameters was also studied. Prevalence of influenza virus infection during study period was 12.37% (145/1175); influenza A was more prevalent (8.7%) than influenza B (3.7%). Positivity for influenza virus was significantly higher in ILI patients (13.9%, 134/961) than SARI patients (5.14%, 11/214). Positivity of influenza peaks significantly correlated with rainfall and dew point while temperature difference and atmospheric pressure were inversely related. No significant correlation was found with humidity and wind speed. Nasal discharge is significantly associated with Influenza A infection while seizers and vomiting are significantly associated with influenza B infection. Pandemic (2009) H1N1 was circulating till October 2010 which was entirely replaced by H3N2 genotype of influenza A. The seasonality of influenza virus infection varies from region to region is associated with environmental factors.