Premium
Influence of physical exercise on cardiac structure and function of spontaneously hypertensive rats
Author(s) -
Pagan Luana Urbano,
Damatto Ricardo Luis,
Cezar Marcelo Diarcadia Mariano,
Gimenes Rodrigo,
Campos Dijon Henrique Salomé,
Lima Aline Regina Ruiz,
Bonomo Camila,
Guizoni Daniele Mendes,
Okoshi Marina Politi,
Okoshi Katashi
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb496
Subject(s) - cardiology , medicine , cardiac function curve , diastole , ex vivo , diastolic function , heart failure , sed , blood pressure , in vitro , chemistry , biochemistry
The aim of this study was to evaluate the influence of physical exercise (PE) on cardiac structure and function of spontaneously hypertensive rats (SHR) before clinical evidence of heart failure (HF). Methods 16 month old SHR were divided into two groups: sedentary (SED, n=14) and exercised (EX, n=14). Physical training was performed 5 times/week for 16 weeks in a treadmill. Arterial pressure (AP) was measured by tail‐cuff method. Echocardiogram (Echo) was performed to evaluate in vivo cardiac structures and left ventricular (LV) function. In vitro myocardial function was analyzed in LV papillary muscle preparations. Statistics: Studentˈs t test (p<0.05). Results AP did not differ between groups (SED: 212±22; EX: 225±20 mmHg). Echo did not show differences in cardiac structures or LV systolic function. Late diastolic mitral annular velocity (Tissue Doppler) was lower in EX group (3.3±0.7 vs 4.2±1.1 cm/s). The in vitro study showed increased contractile function in EX group (developed tension: 7.6±1.8 vs 6.2±1.1 g/mm2; +dT/dt: 67±18 vs 53±10 g/mm2/s). Conclusion PE started before clinical evidence of HF is beneficial on LV diastolic and myocardial contractile functions in SHR. Support: CAPES, CNPq.