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Uropathogens from Qatari Type 2 diabetics with Asymptomatic Bacteruria
Author(s) -
Afifi Nahla M,
Abdullah Asmaa Abdullatef Abu,
Albardawil Haneenn Moee,
Yasin Heba Rashid,
Rouban Wazeera Khaled,
Ewis Soliman A
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb492
Subject(s) - nitrofurantoin , medicine , asymptomatic , virulence , group b , group a , urinary system , antibiotics , bacteriuria , type 2 diabetes , diabetes mellitus , genotype , gastroenterology , ciprofloxacin , microbiology and biotechnology , biology , gene , endocrinology , genetics
The urinary tract infections (UTIs) are among the most common bacterial infections in diabetic patients, especially asymptomatic bacteriuria. The aim of this study is to investigate the causative organisms of ABU in type 2 diabetic patients, the phylogenetic grouping and the antibiotic sensitivity pattern of the causative organism in order to determine the drug of choice to cure ASB in diabetics. Hundred – sixty eight men were recruited from attendance of the out patients clinics at the Army Force Medical Unit in Qatar and twere divided into two groups; Group 1 (130 type 2 diabetics) and Group 2 (38 non‐diabetic subjects). We found that 20% of diabetic patients had ASB and Escherichia coli were the most prevalent pathogen (92.31%). Genotypic study showed that the most prevalent E. coli groups responsible for UTI were belong to group A and B2 (33.3% for each group). Moreover, Nitrofurantoin was the most sensitive antibiotic for the groups B2, B1, D (100%) and 75% for group A. Phenotypic study by SEM showed that there is variation in the diameter, B1 group had the largest width and length (L= 2.391 ± 0.483)(W=622.667 ± 51.215) while group D was the shortest (L=1.876 ± 0.247) and group A had the lowest width (W=580.21 ± 44.93). Further comparing of virulence factors with symptomatic diabetics is required to determine why ASB lacked symptoms in spite the presence of virulence genes.