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Melatonin as key factor on bone remodeling in animal models with perforating fracture
Author(s) -
Kim Koo,
Lee Seunghoon,
Hong Yunkyung,
Lee Minkyung,
Hong Yonggeun
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb483
Subject(s) - melatonin , bone remodeling , femur , medicine , endocrinology , bone healing , chemistry , anatomy , surgery
Bone remodeling is occurred continuously through closely coupled events of osteoclasts, bone‐absorption cells, osteoblasts, and bone‐formation cells in physiological environment. To assess the effect of melatonin on bone remodeling in the femur perforating fractured rats, 8‐week‐old Sprague‐Dawley (SD) rats were treated twice daily with melatonin (10 mg/kg) at 7:00 and 19:00 up to 21 days after surgery for fracture using by micro‐drill. We confirmed that melatonin treated group (MT) was significantly enhanced ALP (p < 0.01), Col‐1 and TRAP mRNA level (p < 0.05) at day 3 after surgery. Whereas vehicle group (Veh) was not at day 3, but significantly increased ALP (p < 0.01) and Col‐1 mRNA¡¡(p < 0.05) mRNA expression at day 14 after surgery. It was closely correlated with histological study in both groups suggesting that melatonin might be as stimulating factor to accelerate of bone remodeling and repair, and should be investigated more experiment afterward to figure out clinical relevant to human patients.