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Differentially expressed genes and lincRNAs throughout oral squamous cell carcinoma development
Author(s) -
Oliveira-Costa João Paulo,
Carvalho Alex Fiorini,
Lourenco Silvia Vanessa,
Kowalski Luiz Paulo,
Carraro Dirce Maria,
Soares Fernando Augusto,
Ribeiro-Silva Alfredo
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb461
Subject(s) - biology , gene , hox gene , basal cell , genome , microarray , intergenic region , genetics , gene expression , computational biology , pathology , medicine
Oral squamous cell carcinoma (OSCC) development still poorly understood, in terms of genome wide alterations leading to high invasiveness and aggressive behavior, and also, which long intergenic non‐coding RNAs (lincRNAs) are differentially expressed throughout its progression. Using 36 OSCC samples, we performed cDNA and lincRNA microarrays, comprising whole human genome and more than 7000 lincRNAs, compairing differentially expressed genes and lincRNAs, from T1 staging to T4 TNM staging. We found 94 genes and 12 lincRNAs with expression increasing or decreasing during OSCC development, including ERBB and HOX families. As the first study adressing OSCC developmental changes in either gene and lincRNAs expression, our results point to differentially expressed protein families that might be aims of deeper studies in OSCC, and the characterization of lincRNA mechanisms in OSCC development.