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Screening for antihypertensive activities of traditional herbs in Donguibogam
Author(s) -
Ok Hyang Mok,
Jung Saet Byeol,
Choi Ye Jin,
Kim Do ram,
Kim Ji Yeon,
Kwon Oran
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb443
Subject(s) - traditional medicine , medicine , medicinal plants
The aim of this study is to examine the all the current science‐based evidence supporting the use of Korean medicinal plants. It was designed to search traditional Korean herbal remedies with specific functionality, antihypertension, in old literatures and systemically prove their effectiveness from a comprehensive, upto‐date literature review and in vitro tests. For a terminology matching related to hypertension symptom, we used primarily Korean Classification of Disease in Oriental Medicine (KCDOM) and Korea Traditional Knowledge Portal (KTKP) databases. Water or ethanol extracts of all the screened plants used in this study were purchased from the Korea Research Institute of Bioscience and Biotechnology (KRIBB). Herbal preparations were investigated in vitro on influence on nitric oxide production and ACE inhibition activity. We used the 15T FT‐ICR MS to identify the chemical fingerprint of major active compounds contained in the selected plants. We found out seventeen kinds of symptoms relevant to hypertension using KCDOM and KTKP and seventy one plants extracts in Donguibogam. The six most potent herbs were identified as Sophorae fructus, Angelicae koreanae, Melonis calyx, Evodiae fructus, Bambusae caulis, and Nepetae spica through in vitro analysis. This study suggests the potential use of traditional plants for antihypertension.